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• Glucosamine Sulphate 1000mg
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How Does Glucosamine Really Work?

The major components of cartilage are water, Glycosaminoglycans (GAG’s), Hyaluronic acid, Proteoglycans, Chondriotin sulphate molecules, Collagen and Elastin. The elements are then held in a collagen matrix, much like a sponge holds water. These elements together form the cushioning and gliding qualities of the joint. In order to maintain these properties of cartilage health, a person needs a nutrient rich diet and an ample supply of Glycosaminoglycans (GAG's), Chondriotin sulphate and Proteoglycans; otherwise the cartilage will begin to break down. Arthritis researchers now believe that it is the decay of Proteoglycans and Glycosaminoglycans that is the central process in the disease process of osteoarthritis and osteoarthrosis. Research focusing on prevention of osteoarthritis seems to point to the use of Glucosamine sulphate to help protect and repair the Proteoglycans in cartilage.
To explain further, firstly healthy cartilage needs three things: water for lubrication and nourishment, Proteoglycans to attract and hold the water, and Collagen to keep the Proteoglycans in place.

Proteoglycans are like a rope that threads itself through the collage and are essential as they hold many times their own weight of water, which both lubricates and nourishes the Collagen. If the cartilage is damaged the thread of rope becomes weak and ‘leaks’ out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. Thus the cartilage cannot withstand shocks, cracks and may wear out completely.
Glucosamine is a major building block of the water, which loves proteoglycans. Besides being a building block for the synthesis of proteoglycans, its mere presence acts as a stimulus to the cells that produce proteoglycans; in fact Glucosamine is a key factor in determining how many proteoglycans the cells produce.

Glucosamine has been shown to speed up production of both proteoglycans and collagen and it normalises cartilage metabolism which helps keep cartilage from breaking down. Thus because of the affect of Glucosamine on cartilage metabolism it can in fact help the body to repair damaged or eroded cartilage. In other words, Glucosamine strengthens your body’s natural repair mechanisms. Besides stimulating cartilage production, Glucosamine also reduces joint pain and inflammation.